Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

Changes in striatal cholinergic interneuron (ChI) activity are thought to contribute to Parkinson’s disease pathophysiology and dyskinesia from chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, but the physiological basis of these changes is unknown. We find that dopamine lesion decreases the...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Se Joon, Ma, Thong C, Ding, Yunmin, Cheung, Timothy, Joshi, Neal, Sulzer, David, Mosharov, Eugene V, Kang, Un Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380940/
https://www.ncbi.nlm.nih.gov/pubmed/32687053
http://dx.doi.org/10.7554/eLife.56920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380940/
https://www.ncbi.nlm.nih.gov/pubmed/32687053
http://dx.doi.org/10.7554/eLife.56920

Ejemplares similares