A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

Directly modulating the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) - two independent pathways for repairing DNA double-strand breaks (DSBs) - has the potential to improve the efficiency of gene targeting by CRISPR/Cas9. Here, we have developed a rapid and easy...

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Detalles Bibliográficos
Autores principales: Zhang, Weina, Chen, Yu, Yang, Jiaqing, Zhang, Jing, Yu, Jiayu, Wang, Mengting, Zhao, Xiaodong, Wei, Ke, Wan, Xiaoping, Xu, Xiaojun, Jiang, Ying, Chen, Jiayu, Gao, Shaorong, Mao, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380943/
https://www.ncbi.nlm.nih.gov/pubmed/32644042
http://dx.doi.org/10.7554/eLife.56008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380943/
https://www.ncbi.nlm.nih.gov/pubmed/32644042
http://dx.doi.org/10.7554/eLife.56008

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