Cargando…

A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

Directly modulating the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) - two independent pathways for repairing DNA double-strand breaks (DSBs) - has the potential to improve the efficiency of gene targeting by CRISPR/Cas9. Here, we have developed a rapid and easy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Weina, Chen, Yu, Yang, Jiaqing, Zhang, Jing, Yu, Jiayu, Wang, Mengting, Zhao, Xiaodong, Wei, Ke, Wan, Xiaoping, Xu, Xiaojun, Jiang, Ying, Chen, Jiayu, Gao, Shaorong, Mao, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380943/ https://www.ncbi.nlm.nih.gov/pubmed/32644042 http://dx.doi.org/10.7554/eLife.56008

Ejemplares similares

Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer
por: Zhang, Weina, et al.
Publicado: (2023)

Methods for in vitro CRISPR/CasRx-Mediated RNA Editing
por: Chuang, Yu-Fan, et al.
Publicado: (2021)

Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation
por: Li, Yanhe, et al.
Publicado: (2020)

Rapid genome editing by CRISPR-Cas9-POLD3 fusion
por: Reint, Ganna, et al.
Publicado: (2021)

Opportunities for CRISPR/Cas9 Gene Editing in Retinal Regeneration Research
por: Campbell, Leah J., et al.
Publicado: (2017)

The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells
por: Chen, Yu, et al.
Publicado: (2020)

A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids
por: Beneke, Tom, et al.
Publicado: (2017)

High-Throughput Genotyping of CRISPR/Cas Edited Cells in 96-Well Plates
por: Nussbaum, Lea, et al.
Publicado: (2018)

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish
por: Ward, Rebecca, et al.
Publicado: (2018)

The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Inherited Diseases
por: Abdelnour, Sameh A., et al.
Publicado: (2021)

CRISPR/Cas9 Delivery Mediated with Hydroxyl‐Rich Nanosystems for Gene Editing in Aorta
por: Zhang, Xiaoping, et al.
Publicado: (2019)

A Complete Study of Farrerol Metabolites Produced In Vivo and In Vitro
por: Yin, Jintuo, et al.
Publicado: (2019)

The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review
por: Qin, Xiaojiang, et al.
Publicado: (2021)

CRISPR-Cas12a System With Synergistic Phage Recombination Proteins for Multiplex Precision Editing in Human Cells
por: Wang, Chengkun, et al.
Publicado: (2022)

Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro
por: He, Jian, et al.
Publicado: (2023)

Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1
por: Liu, Jui-Tung, et al.
Publicado: (2020)

Spatiotemporal control of CRISPR/Cas9 gene editing
por: Zhuo, Chenya, et al.
Publicado: (2021)

Retroelement Insertion in a CRISPR/Cas9 Editing Site in the Early Embryo Intensifies Genetic Mosaicism
por: Jeon, Jeehyun, et al.
Publicado: (2019)

HAP1, a new revolutionary cell model for gene editing using CRISPR-Cas9
por: Llargués-Sistac, Gemma, et al.
Publicado: (2023)

Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies
por: Li, Xueyan, et al.
Publicado: (2015)

Efficient genome editing in plants using a CRISPR/Cas system
por: Feng, Zhengyan, et al.
Publicado: (2013)

Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing
por: Liu, Xingyu, et al.
Publicado: (2022)

An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells
por: Jiang, Yuqian, et al.
Publicado: (2018)

In Vivo Applications of CRISPR-Based Genome Editing in the Retina
por: Yu, Wenhan, et al.
Publicado: (2018)

CRISPR/Cas9 Gene-Editing in Cancer Immunotherapy: Promoting the Present Revolution in Cancer Therapy and Exploring More
por: Ou, Xuejin, et al.
Publicado: (2021)

Fast-Track and Integration-Free Method of Genome Editing by CRISPR/Cas9 in Murine Pluripotent Stem Cells
por: Mamun, Md Mahfuz Al, et al.
Publicado: (2022)

Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis
por: Shi, Zhaoying, et al.
Publicado: (2022)

Farrerol alleviates collagenase‐induced tendinopathy by inhibiting ferroptosis in rats
por: Wu, Yongfu, et al.
Publicado: (2022)

CRISPR–Cas9 Based Bacteriophage Genome Editing
por: Zhang, Xueli, et al.
Publicado: (2022)

Protoplasts: From Isolation to CRISPR/Cas Genome Editing Application
por: Yue, Jin-Jun, et al.
Publicado: (2021)

CRISPR-Cas9 DNA Base-Editing and Prime-Editing
por: Kantor, Ariel, et al.
Publicado: (2020)

Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing
por: Leibowitz, Mitchell L., et al.
Publicado: (2021)

Naïve Induced Pluripotent Stem Cells Generated From β-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9
por: Yang, Yuanyuan, et al.
Publicado: (2016)

Pathological modeling of glycogen storage disease type III with CRISPR/Cas9 edited human pluripotent stem cells
por: Rossiaud, Lucille, et al.
Publicado: (2023)

CRISPR-Cas9-Based Genome Editing and Cytidine Base Editing in Acinetobacter baumannii
por: Wang, Yu, et al.
Publicado: (2020)

Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
por: Zhang, Song, et al.
Publicado: (2021)

Commentary: RNA editing with CRISPR-Cas13
por: Matsoukas, Ianis G.
Publicado: (2018)

Genome Editing in Bacteria: CRISPR-Cas and Beyond
por: Arroyo-Olarte, Ruben D., et al.
Publicado: (2021)

CRISPR/Cas9 or prime editing? – It depends on…
por: Schenke, Dirk
Publicado: (2020)

Computational Tools and Resources for CRISPR/Cas Genome Editing
por: Li, Chao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j9mn88sbj49p99n3etn0q3jrmt