Cargando…

Quantitative Systems Pharmacology Model-Based Predictions of Clinical Endpoints to Optimize Warfarin and Rivaroxaban Anti-Thrombosis Therapy

BACKGROUND: Tight monitoring of efficacy and safety of anticoagulants such as warfarin is imperative to optimize the benefit-risk ratio of anticoagulants in patients. The standard tests used are measurements of prothrombin time (PT), usually expressed as international normalized ratio (INR), and act...

Descripción completa

Detalles Bibliográficos
Autores principales: Hartmann, Sonja, Biliouris, Konstantinos, Lesko, Lawrence J., Nowak-Göttl, Ulrike, Trame, Mirjam N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381140/
https://www.ncbi.nlm.nih.gov/pubmed/32765265
http://dx.doi.org/10.3389/fphar.2020.01041