Cargando…

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice

Alzheimer’s disease (AD) is characterized by the accumulation in the brain of intraneuronal aggregates of abnormally and hyperphosphorylated tau proteins and of extracellular deposits of amyloid-β surrounded by dystrophic neurites. Numerous experimental models have shown that tau pathology develops...

Descripción completa

Detalles Bibliográficos
Autores principales:	Houben, Sarah, de Fisenne, Marie-Ange, Ando, Kunie, Vanden Dries, Virginie, Poncelet, Luc, Yilmaz, Zehra, Mansour, Salwa, De Decker, Robert, Brion, Jean-Pierre, Leroy, Karelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381181/ https://www.ncbi.nlm.nih.gov/pubmed/32765217 http://dx.doi.org/10.3389/fnmol.2020.00106

Ejemplares similares

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis
por: Ando, Kunie, et al.
Publicado: (2021)

Tau Pathology and Adult Hippocampal Neurogenesis: What Tau Mouse Models Tell us?
por: Houben, Sarah, et al.
Publicado: (2021)

de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia
por: Ando, Kunie, et al.
Publicado: (2020)

Dysregulation of Phosphoinositide 5-Phosphatases and Phosphoinositides in Alzheimer's Disease
por: Ando, Kunie, et al.
Publicado: (2021)

PICALM and Alzheimer’s Disease: An Update and Perspectives
por: Ando, Kunie, et al.
Publicado: (2022)

PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease
por: Luna-Viramontes, Nabil Itzi, et al.
Publicado: (2020)

Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6
por: Dangi, Abha, et al.
Publicado: (2020)

Correction: Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6
por: Dangi, Abha, et al.
Publicado: (2022)

The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer’s disease
por: Ando, Kunie, et al.
Publicado: (2020)

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
por: Maina, Mahmoud B., et al.
Publicado: (2021)

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
por: Choi, Hee-Jeong, et al.
Publicado: (2022)

Two-Dimensional Electrophoresis of Tau Mutants Reveals Specific Phosphorylation Pattern Likely Linked to Early Tau Conformational Changes
por: Bretteville, Alexis, et al.
Publicado: (2009)

EuroTau: towing scientists to tau without tautology
por: Mudher, Amrit, et al.
Publicado: (2017)

Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF‐like conformation of Tau protein
por: Manassero, Giusi, et al.
Publicado: (2016)

Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids
por: KrishnaKumar, V. Guru, et al.
Publicado: (2018)

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
por: Strang, Kevin H., et al.
Publicado: (2017)

Computational Insights Into the Inhibition Mechanism of Proanthocyanidin B2 on Tau Hexapeptide (PHF6) Oligomer
por: Li, Qin, et al.
Publicado: (2021)

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice
por: Davtyan, Hayk, et al.
Publicado: (2019)

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
por: Barendrecht, Susan, et al.
Publicado: (2023)

Updated Measurement of the \tau Polarisation in \tau -> \tau(K)\nu_\tau
por: Moraes, D, et al.
Publicado: (1998)

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
por: Cantrelle, François-Xavier, et al.
Publicado: (2021)

Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation
por: van der Harg, Judith M., et al.
Publicado: (2015)

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
por: Laurent, Cyril, et al.
Publicado: (2018)

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach
por: Thomas, Stefani N., et al.
Publicado: (2011)

Effect of Trehalose and Ceftriaxone on the Stability of Aggregating-Prone Tau Peptide Containing PHF6* Sequence: An SRCD Study
por: Honisch, Claudia, et al.
Publicado: (2022)

Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells
por: Panda, Chinmaya, et al.
Publicado: (2021)

Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice
por: Zhong, Suyue, et al.
Publicado: (2023)

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model
por: Shin, Jisu, et al.
Publicado: (2021)

The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory
por: Li, Yuan, et al.
Publicado: (2019)

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy
por: Cherry, Jonathan D., et al.
Publicado: (2016)

The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy
por: Cisternas, Pablo, et al.
Publicado: (2019)

Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
por: Chen, Yijun, et al.
Publicado: (2023)

Untangling Tau: Molecular Insights into Neuroinflammation, Pathophysiology, and Emerging Immunotherapies
por: Davidson, Ryder, et al.
Publicado: (2023)

Stress Granules Modulate SYK to Cause Tau-Associated Neurocognitive Deterioration in 5XFAD Mouse After Anesthesia and Surgery
por: Shen, Yang, et al.
Publicado: (2021)

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
por: Farfara, Dorit, et al.
Publicado: (2023)

Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation
por: Ochoa, Elizabeth, et al.
Publicado: (2023)

Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice
por: Torres, Angie K., et al.
Publicado: (2021)

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
por: Delizannis, Argyro Thalia, et al.
Publicado: (2021)

Search for the decays $B_s^0\to\tau^+\tau^-$ and $B^0\to\tau^+\tau^-$
por: Aaij, Roel, et al.
Publicado: (2017)

High altitude is associated with pTau deposition, neuroinflammation, and myelin loss
por: Iacono, Diego, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_75joo2as9uh99jrdrusrjsc36c