Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease

Several neurological disorders have been linked to mutations in chaperonin genes and more specifically to the HSPD1 gene. In humans, HSPD1 encodes the mitochondrial Heat Shock Protein 60 (mtHsp60) chaperonin, which carries out essential protein folding reactions that help maintain mitochondrial and...

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Detalles Bibliográficos
Autores principales: Rodriguez, Alejandro, Von Salzen, Daniel, Holguin, Bianka A., Bernal, Ricardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381220/
https://www.ncbi.nlm.nih.gov/pubmed/32766281
http://dx.doi.org/10.3389/fmolb.2020.00159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381220/
https://www.ncbi.nlm.nih.gov/pubmed/32766281
http://dx.doi.org/10.3389/fmolb.2020.00159

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