Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous or compound heterozygous gain-of-function mutations in MEFV, encoding pyrin, an inflammasome protein. Heterozygous carrier frequencies for multiple MEFV mutations are high in several Mediterranean populations, sug...

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Detalles Bibliográficos
Autores principales: Park, Yong Hwan, Remmers, Elaine F., Lee, Wonyong, Ombrello, Amanda K., Chung, Lawton K., Shilei, Zhao, Stone, Deborah L., Ivanov, Maya I., Loeven, Nicole A., Barron, Karyl S., Hoffmann, Patrycja, Nehrebecky, Michele, Akkaya-Ulum, Yeliz Z., Sag, Erdal, Balci-Peynircioglu, Banu, Aksentijevich, Ivona, Gül, Ahmet, Rotimi, Charles N., Chen, Hua, Bliska, James B., Ozen, Seza, Kastner, Daniel L., Shriner, Daniel, Chae, Jae Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381377/
https://www.ncbi.nlm.nih.gov/pubmed/32601469
http://dx.doi.org/10.1038/s41590-020-0705-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381377/
https://www.ncbi.nlm.nih.gov/pubmed/32601469
http://dx.doi.org/10.1038/s41590-020-0705-6

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