Cargando…

A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation

In this paper, we present a new approach to deterministic modelling of COVID-19 epidemic. Our model dynamics is expressed by a single prognostic variable which satisfies an integro-differential equation. All unknown parameters are described with a single, time-dependent variable R(t). We show that o...

Descripción completa

Detalles Bibliográficos
Autores principales: Köhler-Rieper, Felix, Röhl, Claudius H. F., De Micheli, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381419/
https://www.ncbi.nlm.nih.gov/pubmed/32834915
http://dx.doi.org/10.1140/epjp/s13360-020-00608-0
_version_ 1783563042935537664
author Köhler-Rieper, Felix
Röhl, Claudius H. F.
De Micheli, Enrico
author_facet Köhler-Rieper, Felix
Röhl, Claudius H. F.
De Micheli, Enrico
author_sort Köhler-Rieper, Felix
collection PubMed
description In this paper, we present a new approach to deterministic modelling of COVID-19 epidemic. Our model dynamics is expressed by a single prognostic variable which satisfies an integro-differential equation. All unknown parameters are described with a single, time-dependent variable R(t). We show that our model has similarities to classic compartmental models, such as SIR, and that the variable R(t) can be interpreted as a generalized effective reproduction number. The advantages of our approach are the simplicity of having only one equation, the numerical stability due to an integral formulation and the reliability since the model is formulated in terms of the most trustable statistical data variable: the number of cumulative diagnosed positive cases of COVID-19. Once this dynamic variable is calculated, other non-dynamic variables, such as the number of heavy cases (hospital beds), the number of intensive-care cases (ICUs) and the fatalities, can be derived from it using a similarly stable, integral approach. The formulation with a single equation allows us to calculate from real data the values of the sample effective reproduction number, which can then be fitted. Extrapolated values of R(t) can be used in the model to make reliable forecasts, though under the assumption that measures for reducing infections are maintained. We have applied our model to more than 15 countries and the ongoing results are available on a web-based platform [1]. In this paper, we focus on the data for two exemplary countries, Italy and Germany, and show that the model is capable of reproducing the course of the epidemic in the past and forecasting its course for a period of four to five weeks with a reasonable numerical stability.
format Online
Article
Text
id pubmed-7381419
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-73814192020-07-28 A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation Köhler-Rieper, Felix Röhl, Claudius H. F. De Micheli, Enrico Eur Phys J Plus Regular Article In this paper, we present a new approach to deterministic modelling of COVID-19 epidemic. Our model dynamics is expressed by a single prognostic variable which satisfies an integro-differential equation. All unknown parameters are described with a single, time-dependent variable R(t). We show that our model has similarities to classic compartmental models, such as SIR, and that the variable R(t) can be interpreted as a generalized effective reproduction number. The advantages of our approach are the simplicity of having only one equation, the numerical stability due to an integral formulation and the reliability since the model is formulated in terms of the most trustable statistical data variable: the number of cumulative diagnosed positive cases of COVID-19. Once this dynamic variable is calculated, other non-dynamic variables, such as the number of heavy cases (hospital beds), the number of intensive-care cases (ICUs) and the fatalities, can be derived from it using a similarly stable, integral approach. The formulation with a single equation allows us to calculate from real data the values of the sample effective reproduction number, which can then be fitted. Extrapolated values of R(t) can be used in the model to make reliable forecasts, though under the assumption that measures for reducing infections are maintained. We have applied our model to more than 15 countries and the ongoing results are available on a web-based platform [1]. In this paper, we focus on the data for two exemplary countries, Italy and Germany, and show that the model is capable of reproducing the course of the epidemic in the past and forecasting its course for a period of four to five weeks with a reasonable numerical stability. Springer Berlin Heidelberg 2020-07-25 2020 /pmc/articles/PMC7381419/ /pubmed/32834915 http://dx.doi.org/10.1140/epjp/s13360-020-00608-0 Text en © Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Regular Article
Köhler-Rieper, Felix
Röhl, Claudius H. F.
De Micheli, Enrico
A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation
title A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation
title_full A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation
title_fullStr A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation
title_full_unstemmed A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation
title_short A novel deterministic forecast model for the Covid-19 epidemic based on a single ordinary integro-differential equation
title_sort novel deterministic forecast model for the covid-19 epidemic based on a single ordinary integro-differential equation
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381419/
https://www.ncbi.nlm.nih.gov/pubmed/32834915
http://dx.doi.org/10.1140/epjp/s13360-020-00608-0
work_keys_str_mv AT kohlerrieperfelix anoveldeterministicforecastmodelforthecovid19epidemicbasedonasingleordinaryintegrodifferentialequation
AT rohlclaudiushf anoveldeterministicforecastmodelforthecovid19epidemicbasedonasingleordinaryintegrodifferentialequation
AT demichelienrico anoveldeterministicforecastmodelforthecovid19epidemicbasedonasingleordinaryintegrodifferentialequation
AT kohlerrieperfelix noveldeterministicforecastmodelforthecovid19epidemicbasedonasingleordinaryintegrodifferentialequation
AT rohlclaudiushf noveldeterministicforecastmodelforthecovid19epidemicbasedonasingleordinaryintegrodifferentialequation
AT demichelienrico noveldeterministicforecastmodelforthecovid19epidemicbasedonasingleordinaryintegrodifferentialequation