Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice

OBJECTIVE: Human TNKS, encoding tankyrase 1 (TNKS1), localizes to a susceptibility locus for obesity and type 2 diabetes mellitus (T2DM). Here, we addressed the therapeutic potential of G007-LK, a TNKS-specific inhibitor, for obesity and T2DM. METHODS: We administered G007-LK to diabetic db/db mice...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Kuusela, Sara, Rinnankoski-Tuikka, Rita, Dumont, Vincent, Bouslama, Rim, Ramadan, Usama Abo, Waaler, Jo, Linden, Anni-Maija, Chi, Nai-Wen, Krauss, Stefan, Pirinen, Eija, Lehtonen, Sanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381423/
https://www.ncbi.nlm.nih.gov/pubmed/32317752
http://dx.doi.org/10.1038/s41366-020-0573-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381423/
https://www.ncbi.nlm.nih.gov/pubmed/32317752
http://dx.doi.org/10.1038/s41366-020-0573-z

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