Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic KRAS has been extremely challenging to target therapeutically. To identify potential vulnerabilities in KRAS-mutated CRC, we characterize the impact of oncogenic KRAS on the cell surface of intestinal epithelial c...

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Detalles Bibliográficos
Autores principales: Aubert, Léo, Nandagopal, Neethi, Steinhart, Zachary, Lavoie, Geneviève, Nourreddine, Sami, Berman, Jacob, Saba-El-Leil, Marc K., Papadopoli, David, Lin, Sichun, Hart, Traver, Macleod, Graham, Topisirovic, Ivan, Gaboury, Louis, Fahrni, Christoph J., Schramek, Daniel, Meloche, Sylvain, Angers, Stephane, Roux, Philippe P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381612/
https://www.ncbi.nlm.nih.gov/pubmed/32709883
http://dx.doi.org/10.1038/s41467-020-17549-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381612/
https://www.ncbi.nlm.nih.gov/pubmed/32709883
http://dx.doi.org/10.1038/s41467-020-17549-y

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