Cargando…

Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates

Medullary thymic epithelial cells (mTEC) contribute to the development of T cell tolerance by expressing and presenting tissue-restricted antigens (TRA), so that developing T cells can assess the self-reactivity of their antigen receptors prior to leaving the thymus. mTEC are a heterogeneous populat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lebel, Marie-Ève, Coutelier, Marie, Galipeau, Maria, Kleinman, Claudia L., Moon, James J., Melichar, Heather J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381629/ https://www.ncbi.nlm.nih.gov/pubmed/32709894 http://dx.doi.org/10.1038/s41467-020-17544-3

Ejemplares similares

mTEC damage risks immune recovery
por: Takahama, Yousuke
Publicado: (2021)

Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution
por: García-León, María Jesús, et al.
Publicado: (2022)

Single-cell RNA-sequencing resolves self-antigen expression during mTEC development
por: Miragaia, Ricardo J., et al.
Publicado: (2018)

Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance
por: This, Sébastien, et al.
Publicado: (2021)

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
por: Pobezinsky, Leonid A., et al.
Publicado: (2012)

TEC Installation
por: CERN. Geneva. Audiovisual Unit
Publicado: (1989)

Production of autoreactive I region-restricted T cell hybridomas
Publicado: (1982)

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8(+) T Cells
por: Kurts, Christian, et al.
Publicado: (1997)

Antigen presentation by human autoreactive PLP specific T-cell clones
por: Correale, J., et al.
Publicado: (1994)

Origin and specificity of autoreactive T cells in antigen-induced populations
Publicado: (1985)

The ICOS–ICOSL pathway tunes thymic selection
por: Dong, Mengqi, et al.
Publicado: (2022)

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk
por: Ellmeier, Wilfried, et al.
Publicado: (2000)

Induction of autoreactive B cells allows priming of autoreactive T cells
Publicado: (1991)

The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope
Publicado: (1988)

Novel approaches for identifying target antigens of autoreactive human B and T cells
por: Dornmair, Klaus, et al.
Publicado: (2009)

Images of the CMS Tracker Endcap (TEC)
por: Brice, M
Publicado: (2008)

A comparison between TEC obtained by the TOPEX/Poseidon borne GPS receiver and TEC from the Gallagher model
por: Ciraolo, L
Publicado: (2002)

Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation
por: Lau, Ching-In, et al.
Publicado: (2018)

Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains
por: Volpe, Joseph M, et al.
Publicado: (2009)

The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells
por: Ferry, Helen, et al.
Publicado: (2003)

Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
por: Enouz, Sarah, et al.
Publicado: (2012)

Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens
por: Tian, Jide, et al.
Publicado: (2009)

Antigen Recognition By Autoreactive Cd4(+) Thymocytes Drives Homeostasis Of The Thymic Medulla
por: Irla, Magali, et al.
Publicado: (2012)

Are Induced/altered Self-peptide Antigens Responsible for De Novo Autoreactivity in Transplantation?
por: Sharland, Alexandra F., et al.
Publicado: (2023)

A new tool for assessing the cultural adaptation of cognitive tests: demonstrating the utility of the Manchester Translation Evaluation Checklist (MTEC) through the Mini-Mental State Examination Urdu
por: Mirza, Nadine, et al.
Publicado: (2022)

Salvamento arqueológico Campos Tec., : Fortin de las Flores, Veracruz
por: Cuervo Zarate, Nancy
Publicado: (2011)

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells
por: Kristyanto, Hendy, et al.
Publicado: (2022)

MHC-restricted minimal regulatory circuit initiated by a class II- autoreactive T cell clone
Publicado: (1987)

Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells
por: Clark, Matthew, et al.
Publicado: (2021)

Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis
por: Prinz, Jörg Christoph
Publicado: (2018)

Polar Topside TEC Enhancement Revealed by Jason‐2 Measurements
por: Pi, Xiaoqing, et al.
Publicado: (2021)

CD5 levels define functionally heterogeneous populations of naïve human CD4(+) T cells
por: Sood, Aditi, et al.
Publicado: (2021)

The secret autoreactivity of B cells
por: Williams, Ruth
Publicado: (2007)

Autoreactivity patterns in rheumatoid arthritis
por: Behrens, S, et al.
Publicado: (2001)

The broad spectrum of pathogenic autoreactivity
por: Santambrogio, Laura, et al.
Publicado: (2022)

Comparisons of IRI global TEC maps with CODE GIMs
por: Coisson, P, et al.
Publicado: (2002)

Action control according to TEC (theory of event coding)
por: Hommel, Bernhard
Publicado: (2009)

The theory of event coding (TEC) as embodied-cognition framework
por: Hommel, Bernhard
Publicado: (2015)

FaceTec ties the knot with dating app firm
Publicado: (2020)

Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis
por: Jackman, Rachael P, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nus85b044g31b6fhk55es79d8n