DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the targe...

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Detalles Bibliográficos
Autores principales: Adam, Sabrina, Anteneh, Hiwot, Hornisch, Maximilian, Wagner, Vincent, Lu, Jiuwei, Radde, Nicole E., Bashtrykov, Pavel, Song, Jikui, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381644/
https://www.ncbi.nlm.nih.gov/pubmed/32709850
http://dx.doi.org/10.1038/s41467-020-17531-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381644/
https://www.ncbi.nlm.nih.gov/pubmed/32709850
http://dx.doi.org/10.1038/s41467-020-17531-8

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