Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway

OBJECTIVE: Salt-induced kinase 1 (SIK1) acts as a key modulator in many physiological processes. However, the effects of SIK1 on gluconeogenesis and the underlying mechanisms have not been fully elucidated. In this study, we found that a natural compound phanginin A could activate SIK1 and further i...

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Detalles Bibliográficos
Autores principales: Liu, Siwen, Huang, Suling, Wu, Xingde, Feng, Ying, Shen, Yu, Zhao, Qin-shi, Leng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381706/
https://www.ncbi.nlm.nih.gov/pubmed/32599076
http://dx.doi.org/10.1016/j.molmet.2020.101045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381706/
https://www.ncbi.nlm.nih.gov/pubmed/32599076
http://dx.doi.org/10.1016/j.molmet.2020.101045

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