Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity

Rationale: Dysfunction or reduced levels of EAAT2 have been documented in epilepsy. We previously demonstrated the antiepileptic effects of Hsp90 inhibitor 17AAG in temporal lobe epilepsy by preventing EAAT2 degradation. Because of the potential toxicities of 17AAG, this study aimed to identify an a...

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Detalles Bibliográficos
Autores principales: Sha, Longze, Chen, Ting, Deng, Yu, Du, Tingfu, Ma, Kaili, Zhu, Wanwan, Shen, Yan, Xu, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381737/
https://www.ncbi.nlm.nih.gov/pubmed/32724478
http://dx.doi.org/10.7150/thno.44721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381737/
https://www.ncbi.nlm.nih.gov/pubmed/32724478
http://dx.doi.org/10.7150/thno.44721

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