Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library

DNA-encoded chemical libraries are collections of compounds individually coupled to unique DNA tags serving as amplifiable identification barcodes. By bridging split-and-pool combinatorial synthesis with the ligation of unique encoding DNA oligomers, million- to billion-member libraries can be synth...

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Detalles Bibliográficos
Autores principales: Dawadi, Surendra, Simmons, Nicholas, Miklossy, Gabriella, Bohren, Kurt M., Faver, John C., Ucisik, Melek Nihan, Nyshadham, Pranavanand, Yu, Zhifeng, Matzuk, Martin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382296/
https://www.ncbi.nlm.nih.gov/pubmed/32641511
http://dx.doi.org/10.1073/pnas.2005447117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382296/
https://www.ncbi.nlm.nih.gov/pubmed/32641511
http://dx.doi.org/10.1073/pnas.2005447117

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