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Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library
DNA-encoded chemical libraries are collections of compounds individually coupled to unique DNA tags serving as amplifiable identification barcodes. By bridging split-and-pool combinatorial synthesis with the ligation of unique encoding DNA oligomers, million- to billion-member libraries can be synth...
Autores principales: | Dawadi, Surendra, Simmons, Nicholas, Miklossy, Gabriella, Bohren, Kurt M., Faver, John C., Ucisik, Melek Nihan, Nyshadham, Pranavanand, Yu, Zhifeng, Matzuk, Martin M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382296/ https://www.ncbi.nlm.nih.gov/pubmed/32641511 http://dx.doi.org/10.1073/pnas.2005447117 |
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