Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

APOE4 is a major risk factor for sporadic Alzheimer’s disease; however, it is unclear how it exerts its pathological effects. Others and we have previously shown that autophagy is impaired in APOE4 compared to APOE3 astrocytes, and demonstrated differences in the expression of mitochondrial dynamics...

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Detalles Bibliográficos
Autores principales: Schmukler, Eran, Solomon, Shira, Simonovitch, Shira, Goldshmit, Yona, Wolfson, Eya, Michaelson, Daniel Morris, Pinkas-Kramarski, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382473/
https://www.ncbi.nlm.nih.gov/pubmed/32709881
http://dx.doi.org/10.1038/s41419-020-02776-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382473/
https://www.ncbi.nlm.nih.gov/pubmed/32709881
http://dx.doi.org/10.1038/s41419-020-02776-4

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