PRMT5 promotes cancer cell migration and invasion through the E2F pathway

The pRb-E2F pathway is a critical point of regulation in the cell cycle and loss of control of the pathway is a hallmark of cancer. E2F1 is the major target through which pRb exerts its effects and arginine methylation by PRMT5 plays a key role in dictating E2F1 activity. Here we have explored the f...

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Detalles Bibliográficos
Autores principales: Barczak, Wojciech, Jin, Li, Carr, Simon Mark, Munro, Shonagh, Ward, Samuel, Kanapin, Alexander, Samsonova, Anastasia, La Thangue, Nicholas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382496/
https://www.ncbi.nlm.nih.gov/pubmed/32709847
http://dx.doi.org/10.1038/s41419-020-02771-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382496/
https://www.ncbi.nlm.nih.gov/pubmed/32709847
http://dx.doi.org/10.1038/s41419-020-02771-9

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