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External Validation of Model-Based Dosing Guidelines for Vancomycin, Gentamicin, and Tobramycin in Critically Ill Neonates and Children: A Pragmatic Two-Center Study

BACKGROUND: The Dutch Pediatric Formulary (DPF) increasingly bases its guidelines on model-based dosing simulations from pharmacokinetic studies. This resulted in nationwide dose changes for vancomycin, gentamicin, and tobramycin in 2015. OBJECTIVE: We aimed to evaluate target attainment of these al...

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Detalles Bibliográficos
Autores principales:	Hartman, Stan J. F., Orriëns, Lynn B., Zwaag, Samanta M., Poel, Tim, de Hoop, Marika, de Wildt, Saskia N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383037/ https://www.ncbi.nlm.nih.gov/pubmed/32507958 http://dx.doi.org/10.1007/s40272-020-00400-8

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