BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes

Diabetic cardiomyopathy (DCM) is a major cause of mortality/morbidity in diabetes mellitus patients. Although tetrahydrobiopterin (BH4) shows therapeutic potential as an endogenous cardiovascular target, its effect on myocardial cells and mitochondria in DCM and the underlying mechanisms remain unkn...

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Detalles Bibliográficos
Autores principales: Kim, Hyoung Kyu, Ko, Tae Hee, Song, In-Sung, Jeong, Yu Jeong, Heo, Hye Jin, Jeong, Seung Hun, Kim, Min, Park, Nam Mi, Seo, Dae Yun, Kha, Pham Trong, Kim, Sun-Woo, Lee, Sung Ryul, Cho, Sung Woo, Won, Jong Chul, Youm, Jae Boum, Ko, Kyung Soo, Rhee, Byoung Doo, Kim, Nari, Cho, Kyoung Im, Shimizu, Ippei, Minamino, Tohru, Ha, Nam-Chul, Park, Young Shik, Nilius, Bernd, Han, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383063/
https://www.ncbi.nlm.nih.gov/pubmed/32699151
http://dx.doi.org/10.26508/lsa.201900619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383063/
https://www.ncbi.nlm.nih.gov/pubmed/32699151
http://dx.doi.org/10.26508/lsa.201900619

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