Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies

Mitochondrial dysfunction has long been implicated in the neurodegenerative disorder Parkinson's disease (PD); however, it is unclear how mitochondrial impairment and α-synuclein pathology are coupled. Using specific mitochondrial inhibitors, EM analysis, and biochemical assays, we report here...

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Detalles Bibliográficos
Autores principales: Lautenschläger, Janin, Wagner-Valladolid, Sara, Stephens, Amberley D., Fernández-Villegas, Ana, Hockings, Colin, Mishra, Ajay, Manton, James D., Fantham, Marcus J., Lu, Meng, Rees, Eric J., Kaminski, Clemens F., Kaminski Schierle, Gabriele S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383368/
https://www.ncbi.nlm.nih.gov/pubmed/32385113
http://dx.doi.org/10.1074/jbc.RA119.011650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383368/
https://www.ncbi.nlm.nih.gov/pubmed/32385113
http://dx.doi.org/10.1074/jbc.RA119.011650

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