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Total Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)‐Diastereoisomer

The first total synthesis of vioprolide D was accomplished in an overall yield of 2.0 % starting from methyl (2S)‐3‐benzyloxy‐2‐hydroxypropanoate (16 steps in the longest linear sequence). The cyclic depsipeptide was assembled from two building blocks of similar size and complexity in a modular, hig...

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Detalles Bibliográficos
Autores principales: Grab, Hanusch A., Kirsch, Volker C., Sieber, Stephan A., Bach, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383572/
https://www.ncbi.nlm.nih.gov/pubmed/32126146
http://dx.doi.org/10.1002/anie.202002328