Computational Design of Enantiocomplementary Epoxide Hydrolases for Asymmetric Synthesis of Aliphatic and Aromatic Diols

The use of enzymes in preparative biocatalysis often requires tailoring enzyme selectivity by protein engineering. Herein we explore the use of computational library design and molecular dynamics simulations to create variants of limonene epoxide hydrolase that produce enantiomeric diols from meso‐e...

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Detalles Bibliográficos
Autores principales: Arabnejad, Hesam, Bombino, Elvira, Colpa, Dana I., Jekel, Peter A., Trajkovic, Milos, Wijma, Hein J., Janssen, Dick B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383614/
https://www.ncbi.nlm.nih.gov/pubmed/31961471
http://dx.doi.org/10.1002/cbic.201900726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383614/
https://www.ncbi.nlm.nih.gov/pubmed/31961471
http://dx.doi.org/10.1002/cbic.201900726

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