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PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers
Poly[adenosine diphosphate (ADP) ribose]polymerase (PARP) has multifaceted roles in the maintenance of genomic integrity, deoxyribonucleic acid (DNA) repair and replication, and the maintenance of immune-system homeostasis. PARP inhibitors are an attractive oncologic therapy, causing direct cancer c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383615/ https://www.ncbi.nlm.nih.gov/pubmed/32782491 http://dx.doi.org/10.1177/1758835920944116 |