Cargando…

Sequence‐Based Prediction of Promiscuous Acyltransferase Activity in Hydrolases

Certain hydrolases preferentially catalyze acyl transfer over hydrolysis in an aqueous environment. However, the molecular and structural reasons for this phenomenon are still unclear. Herein, we provide evidence that acyltransferase activity in esterases highly correlates with the hydrophobicity of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Müller, Henrik, Becker, Ann‐Kristin, Palm, Gottfried J., Berndt, Leona, Badenhorst, Christoffel P. S., Godehard, Simon P., Reisky, Lukas, Lammers, Michael, Bornscheuer, Uwe T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383625/ https://www.ncbi.nlm.nih.gov/pubmed/32243661 http://dx.doi.org/10.1002/anie.202003635

Ejemplares similares

Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases
por: Müller, Henrik, et al.
Publicado: (2020)

Recovery of Hydroxytyrosol from Olive Mill Wastewater Using the Promiscuous Hydrolase/Acyltransferase PestE
por: Terholsen, Henrik, et al.
Publicado: (2022)

Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate
por: Palm, Gottfried J., et al.
Publicado: (2019)

Rational Design for Enhanced Acyltransferase Activity in Water Catalyzed by the Pyrobaculum calidifontis VA1 Esterase
por: Staudt, Amanda, et al.
Publicado: (2021)

Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase
por: Pfaff, Lara, et al.
Publicado: (2022)

Mechanism-Based Design of Efficient PET Hydrolases
por: Wei, Ren, et al.
Publicado: (2022)

From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases
por: Tang, Qingyun, et al.
Publicado: (2021)

Specificity and mechanism of carbohydrate demethylation by cytochrome P450 monooxygenases
por: Robb, Craig S., et al.
Publicado: (2018)

Recent trends in biocatalysis
por: Yi, Dong, et al.
Publicado: (2021)

Enlightening the Path to Protein Engineering: Chemoselective Turn-On Probes for High-Throughput Screening of Enzymatic Activity
por: Hecko, Sebastian, et al.
Publicado: (2023)

Probing the mechanisms for the selectivity and promiscuity of methyl parathion hydrolase
por: Purg, Miha, et al.
Publicado: (2016)

Engineering and evaluation of thermostable IsPETase variants for PET degradation
por: Brott, Stefan, et al.
Publicado: (2021)

Promiscuous activity of C-acyltransferase from Pseudomonas protegens: synthesis of acetanilides in aqueous buffer
por: Żądło-Dobrowolska, Anna, et al.
Publicado: (2018)

Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs
por: Tang, Qingyun, et al.
Publicado: (2020)

Computational design of an amidase by combining the best electrostatic features of two promiscuous hydrolases
por: Galmés, Miquel À., et al.
Publicado: (2022)

Structural Basis for (2R,3R)-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus
por: Palm, Gottfried J., et al.
Publicado: (2022)

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria
por: Agnew, Thomas, et al.
Publicado: (2018)

EP-Pred: A Machine Learning Tool for Bioprospecting Promiscuous Ester Hydrolases
por: Xiang, Ruite, et al.
Publicado: (2022)

Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation
por: Fung, Danny K., et al.
Publicado: (2022)

Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F(420) and Its Derivative 3PG-F(420)
por: Hasan, Mahmudul, et al.
Publicado: (2022)

Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β‐Hydroxylation of Lithocholic Acid
por: Grobe, Sascha, et al.
Publicado: (2020)

Unique alcohol dehydrogenases involved in algal sugar utilization by marine bacteria
por: Brott, Stefan, et al.
Publicado: (2023)

Promiscuous Defluorinating Enoyl-CoA Hydratases/Hydrolases Allow for Complete Anaerobic Degradation of 2-Fluorobenzoate
por: Tiedt, Oliver, et al.
Publicado: (2017)

A new carbohydrate-active oligosaccharide dehydratase is involved in the degradation of ulvan
por: Bäumgen, Marcus, et al.
Publicado: (2021)

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
por: Mencher, Simon K, et al.
Publicado: (2005)

Promiscuous words
por: Elgar, Mark A, et al.
Publicado: (2013)

Promiscuous Ligands
por: McGovern, S.L.
Publicado: (2007)

Are PARPs promiscuous?
por: Feijs, Karla L.H., et al.
Publicado: (2022)

Ylehd, an epoxide hydrolase with promiscuous haloalkane dehalogenase activity from tropical marine yeast Yarrowia lipolytica is induced upon xenobiotic stress
por: Bendigiri, Chandrika, et al.
Publicado: (2017)

Data structures for compound promiscuity analysis: promiscuity cliffs, pathways and promiscuity hubs formed by inhibitors of the human kinome
por: Miljković, Filip, et al.
Publicado: (2019)

Glycerophosphate/Acylglycerophosphate Acyltransferases
por: Yamashita, Atsushi, et al.
Publicado: (2014)

An Ultrasensitive Fluorescence Assay for the Detection of Halides and Enzymatic Dehalogenation
por: Aslan‐Üzel, Aşkın S., et al.
Publicado: (2020)

Metabolic engineering enables Bacillus licheniformis to grow on the marine polysaccharide ulvan
por: Dutschei, Theresa, et al.
Publicado: (2022)

Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context‐Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space
por: Bayer, Christopher D., et al.
Publicado: (2017)

Effect of Single and Combined Expression of Lysophosphatidic Acid Acyltransferase, Glycerol-3-Phosphate Acyltransferase, and Diacylglycerol Acyltransferase on Lipid Accumulation and Composition in Neochloris oleoabundans
por: Muñoz, Camilo F., et al.
Publicado: (2019)

Exploiting the promiscuity of imatinib
por: Lee, Shun J, et al.
Publicado: (2009)

Substrate recruitment by zDHHC protein acyltransferases
por: Malgapo, Martin Ian P., et al.
Publicado: (2021)

Structure, mechanism, and inhibition of Hedgehog acyltransferase
por: Coupland, Claire E., et al.
Publicado: (2021)

Alcohol acyltransferases for the biosynthesis of esters
por: Liu, Gaofei, et al.
Publicado: (2023)

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding
por: Coan, Kristin E. D., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_82hogml1jiqe4f1pva3p9ahcbj