Changes in perampanel levels during de‐induction: Simulations following carbamazepine discontinuation

OBJECTIVE: To evaluate the time course of changes in perampanel levels when co‐administered with carbamazepine, and following carbamazepine discontinuation, using a physiologically based pharmacokinetic (PBPK) model. METHODS: The PBPK model was developed, verified using clinical PK data, and used to...

Descripción completa

Detalles Bibliográficos
Autores principales: Schuck, Edgar, Ferry, Jim, Gidal, Barry, Hussein, Ziad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383646/
https://www.ncbi.nlm.nih.gov/pubmed/32430908
http://dx.doi.org/10.1111/ane.13286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383646/
https://www.ncbi.nlm.nih.gov/pubmed/32430908
http://dx.doi.org/10.1111/ane.13286

Ejemplares similares