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Changes in perampanel levels during de‐induction: Simulations following carbamazepine discontinuation

OBJECTIVE: To evaluate the time course of changes in perampanel levels when co‐administered with carbamazepine, and following carbamazepine discontinuation, using a physiologically based pharmacokinetic (PBPK) model. METHODS: The PBPK model was developed, verified using clinical PK data, and used to...

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Detalles Bibliográficos
Autores principales:	Schuck, Edgar, Ferry, Jim, Gidal, Barry, Hussein, Ziad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383646/ https://www.ncbi.nlm.nih.gov/pubmed/32430908 http://dx.doi.org/10.1111/ane.13286

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