Cargando…
Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats
OBJECTIVE: Approximately 30% of patients with epilepsy do not experience full seizure control on their antiseizure drug (ASD) regimen. Historically, screening for novel ASDs has relied on evaluating efficacy following a single administration of a test compound in either acute electrical or chemical...
Autores principales: | Thomson, Kyle E., Metcalf, Cameron S., Newell, Thomas G., Huff, Jennifer, Edwards, Sharon F., West, Peter J., Wilcox, Karen S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383749/ https://www.ncbi.nlm.nih.gov/pubmed/32420627 http://dx.doi.org/10.1111/epi.16531 |
Ejemplares similares
-
Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine‐resistant amygdala kindling model
por: Metcalf, Cameron S., et al.
Publicado: (2019) -
Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program
por: Pernici, Chelsea D., et al.
Publicado: (2021) -
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs
por: West, Peter J., et al.
Publicado: (2022) -
Screening of prototype antiseizure and anti‐inflammatory compounds in the Theiler's murine encephalomyelitis virus model of epilepsy
por: Metcalf, Cameron S., et al.
Publicado: (2021) -
Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats
por: Lumley, Lucille A., et al.
Publicado: (2021)