Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage

Alkaptonuria (AKU) is a rare disease characterized by high levels of homogentisic acid (HGA); patients suffer from tissue ochronosis: dark brown pigmentation, especially of joint cartilage, leading to severe early osteoarthropathy. No molecular mechanism links elevated HGA to ochronosis; the pigment...

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Detalles Bibliográficos
Autores principales: Chow, Wing Ying, Norman, Brendan P., Roberts, Norman B., Ranganath, Lakshminarayan R., Teutloff, Christian, Bittl, Robert, Duer, Melinda J., Gallagher, James A., Oschkinat, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383862/
https://www.ncbi.nlm.nih.gov/pubmed/32219972
http://dx.doi.org/10.1002/anie.202000618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383862/
https://www.ncbi.nlm.nih.gov/pubmed/32219972
http://dx.doi.org/10.1002/anie.202000618

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