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Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow
We report the preparation of lithium‐salt‐free KDA (potassium diisopropylamide; 0.6 m in hexane) complexed with TMEDA (N,N,N′,N′‐tetramethylethylenediamine) and its use for the flow‐metalation of (hetero)arenes between −78 °C and 25 °C with reaction times between 0.2 s and 24 s and a combined flow r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383875/ https://www.ncbi.nlm.nih.gov/pubmed/32216119 http://dx.doi.org/10.1002/anie.202003392 |