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In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET

INTRODUCTION: Synaptic loss is a robust and consistent pathology in Alzheimer's disease (AD) and the major structural correlate of cognitive impairment. Positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising biomarker of synaptic density...

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Detalles Bibliográficos
Autores principales: Mecca, Adam P., Chen, Ming‐Kai, O'Dell, Ryan S., Naganawa, Mika, Toyonaga, Takuya, Godek, Tyler A., Harris, Joanna E., Bartlett, Hugh H., Zhao, Wenzhen, Nabulsi, Nabeel B., Wyk, Brent C. Vander, Varma, Pradeep, Arnsten, Amy F. T., Huang, Yiyun, Carson, Richard E., van Dyck, Christopher H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383876/
https://www.ncbi.nlm.nih.gov/pubmed/32400950
http://dx.doi.org/10.1002/alz.12097