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In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
INTRODUCTION: Synaptic loss is a robust and consistent pathology in Alzheimer's disease (AD) and the major structural correlate of cognitive impairment. Positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising biomarker of synaptic density...
Autores principales: | Mecca, Adam P., Chen, Ming‐Kai, O'Dell, Ryan S., Naganawa, Mika, Toyonaga, Takuya, Godek, Tyler A., Harris, Joanna E., Bartlett, Hugh H., Zhao, Wenzhen, Nabulsi, Nabeel B., Wyk, Brent C. Vander, Varma, Pradeep, Arnsten, Amy F. T., Huang, Yiyun, Carson, Richard E., van Dyck, Christopher H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383876/ https://www.ncbi.nlm.nih.gov/pubmed/32400950 http://dx.doi.org/10.1002/alz.12097 |
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