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Sleep deprivation regulates availability of PrP(C) and Aβ peptides which can impair interaction between PrP(C) and laminin and neuronal plasticity
PrP(C) is a glycoprotein capable to interact with several molecules and mediates diverse signaling pathways. Among numerous ligands, laminin (LN) is known to promote neurite outgrowth and memory consolidation, while amyloid‐beta oligomers (Aβo) trigger synaptic dysfunction. In both pathways, mGluR1...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383904/ https://www.ncbi.nlm.nih.gov/pubmed/31950499 http://dx.doi.org/10.1111/jnc.14960 |