Reductive Deamination with Hydrosilanes Catalyzed by B(C(6)F(5))(3)

The strong boron Lewis acid tris(pentafluorophenyl)borane B(C(6)F(5))(3) is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C−N bond and defunctionalization is...

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Detalles Bibliográficos
Autores principales: Fang, Huaquan, Oestreich, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384015/
https://www.ncbi.nlm.nih.gov/pubmed/32311213
http://dx.doi.org/10.1002/anie.202004651
Descripción
Sumario:The strong boron Lewis acid tris(pentafluorophenyl)borane B(C(6)F(5))(3) is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C−N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition‐metal‐free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and an isothiocyanate.

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