Enhancing the sensitivity of the thymidine kinase assay by using DNA repair‐deficient human TK6 cells

The OECD guidelines define the bioassays of identifying mutagenic chemicals, including the thymidine kinase (TK) assay, which specifically detects the mutations that inactivate the TK gene in the human TK6 lymphoid line. However, the sensitivity of this assay is limited because it detects mutations...

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Detalles Bibliográficos
Autores principales: Ibrahim, Mahmoud Abdelghany, Yasui, Manabu, Saha, Liton Kumar, Sasanuma, Hiroyuki, Honma, Masamitsu, Takeda, Shunichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384079/
https://www.ncbi.nlm.nih.gov/pubmed/32243652
http://dx.doi.org/10.1002/em.22371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384079/
https://www.ncbi.nlm.nih.gov/pubmed/32243652
http://dx.doi.org/10.1002/em.22371

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