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NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase
Dihydronicotinamide riboside (NRH) was suggested to act as a precursor for the synthesis of NAD(+) but the biochemical pathway converting it has been unknown. Here we show that NRH can be converted into NAD(+) via a salvage pathway in which adenosine kinase (AK) acts as an NRH kinase. Using isotope...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384296/ https://www.ncbi.nlm.nih.gov/pubmed/32694608 http://dx.doi.org/10.1038/s42255-020-0194-9 |