Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2)

A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [(11)C]CO(2) and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling me...

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Autores principales: Bongarzone, Salvatore, Raucci, Nicola, Fontana, Igor Camargo, Luzi, Federico, Gee, Antony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384297/
https://www.ncbi.nlm.nih.gov/pubmed/32211652
http://dx.doi.org/10.1039/d0cc00449a
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author Bongarzone, Salvatore
Raucci, Nicola
Fontana, Igor Camargo
Luzi, Federico
Gee, Antony D.
author_facet Bongarzone, Salvatore
Raucci, Nicola
Fontana, Igor Camargo
Luzi, Federico
Gee, Antony D.
author_sort Bongarzone, Salvatore
collection PubMed
description A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [(11)C]CO(2) and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [(11)C]CO(2) delivery with a trapping efficiency of 21–89%.
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spelling pubmed-73842972020-08-13 Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2) Bongarzone, Salvatore Raucci, Nicola Fontana, Igor Camargo Luzi, Federico Gee, Antony D. Chem Commun (Camb) Chemistry A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [(11)C]CO(2) and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [(11)C]CO(2) delivery with a trapping efficiency of 21–89%. Royal Society of Chemistry 2020-04-30 2020-03-25 /pmc/articles/PMC7384297/ /pubmed/32211652 http://dx.doi.org/10.1039/d0cc00449a Text en This journal is © The Royal Society of Chemistry 2020 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Bongarzone, Salvatore
Raucci, Nicola
Fontana, Igor Camargo
Luzi, Federico
Gee, Antony D.
Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2)
title Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2)
title_full Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2)
title_fullStr Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2)
title_full_unstemmed Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2)
title_short Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)C]CO(2)
title_sort carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [(11)c]co(2)
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384297/
https://www.ncbi.nlm.nih.gov/pubmed/32211652
http://dx.doi.org/10.1039/d0cc00449a
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