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The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice

During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, we evaluated the epigenetic landscape of the mouse myometrium...

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Detalles Bibliográficos
Autores principales: Shchuka, Virlana M., Abatti, Luis E., Hou, Huayun, Khader, Nawrah, Dorogin, Anna, Wilson, Michael D., Shynlova, Oksana, Mitchell, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384763/
https://www.ncbi.nlm.nih.gov/pubmed/32667910
http://dx.doi.org/10.1371/journal.pbio.3000710