Cargando…

Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF-1α and Oct4

It has been controversial whether patients with hepatocellular carcinoma (HCC) should receive glucocorticoid therapy during chemotherapy. Recent studies have demonstrated that glucocorticoids increase the therapeutic sensitivity of tumors to some chemotherapeutic drugs, but the specific mechanism re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Zhongmin, Zhang, Chunyan, Liu, Xiaozhi, Ma, Xiaofang, Bian, Xiyun, Xiao, Xiaolin, Gao, Rui, Sun, Yajing, Wu, WenHan, Zhao, Po
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384854/ https://www.ncbi.nlm.nih.gov/pubmed/32705164 http://dx.doi.org/10.3892/ijo.2020.5097

Ejemplares similares

Saikosaponin D improves chemosensitivity of glioblastoma by reducing the its stemness maintenance
por: Liang, Jin, et al.
Publicado: (2022)

Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation
por: Abdel-Hafiz, Hany A, et al.
Publicado: (2012)

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
por: Cui, Chun-Ping, et al.
Publicado: (2017)

Mild Hypothermia Promotes Ischemic Tolerance and Survival of Neural Stem Cell Grafts by Enhancing Global SUMOylation
por: Cai, Heng, et al.
Publicado: (2022)

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals
por: Vergari, Elisa, et al.
Publicado: (2012)

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response
por: Du, Shi-chun, et al.
Publicado: (2019)

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
por: Yu, Luyang, et al.
Publicado: (2010)

Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression
por: Tong, Yingying, et al.
Publicado: (2022)

Zinc-Induced SUMOylation of Dynamin-Related Protein 1 Protects the Heart against Ischemia-Reperfusion Injury
por: Bian, Xiyun, et al.
Publicado: (2019)

Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation
por: Sun, Hao, et al.
Publicado: (2014)

Inhibition of p53 deSUMOylation Exacerbates Puromycin Aminonucleoside-Induced Apoptosis in Podocytes
por: Wang, Lingyu, et al.
Publicado: (2014)

Revised nomenclature and functional overview of the ULP gene family of plant deSUMOylating proteases
por: Castro, Pedro Humberto, et al.
Publicado: (2018)

Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury
por: Rawlings, Nadiia, et al.
Publicado: (2019)

DeSUMOylation of Apoptosis Inhibitor 5 by Avibirnavirus VP3 Supports Virus Replication
por: Deng, Tingjuan, et al.
Publicado: (2021)

Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation
por: Liu, Xiaozhi, et al.
Publicado: (2017)

SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1
por: Xia, Nansong, et al.
Publicado: (2016)

SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
por: Yu, Xiaoyan, et al.
Publicado: (2018)

SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T
por: Tao, Yifeng, et al.
Publicado: (2020)

Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling
por: Barysch, Sina V, et al.
Publicado: (2021)

SUMO/deSUMOylation of the BRI1 brassinosteroid receptor modulates plant growth responses to temperature
por: Naranjo-Arcos, Maria, et al.
Publicado: (2023)

Ginkgolic acid improves bleomycin-induced pulmonary fibrosis by inhibiting SMAD4 SUMOylation
por: Yu, Lan, et al.
Publicado: (2022)

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
por: Guo, Chun, et al.
Publicado: (2017)

SENP6-Mediated deSUMOylation of VEGFR2 Enhances Its Cell Membrane Transport in Angiogenesis
por: He, Qi, et al.
Publicado: (2023)

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation
por: Claessens, Laura A., et al.
Publicado: (2023)

Moderate hypothermia induces protection against hypoxia/reoxygenation injury by enhancing SUMOylation in cardiomyocytes
por: Chen, Jinsheng, et al.
Publicado: (2020)

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia
por: Guo, Chun, et al.
Publicado: (2013)

SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression
por: Shao, Lan, et al.
Publicado: (2015)

The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis
por: Qiu, Cong, et al.
Publicado: (2017)

SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance
por: Li, Jing, et al.
Publicado: (2021)

SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair
por: Han, Yang, et al.
Publicado: (2022)

SUMO specific peptidase 3 halts pancreatic ductal adenocarcinoma metastasis via deSUMOylating DKC1
por: Wu, Xiao, et al.
Publicado: (2023)

DeSUMOylation of chromatin-bound proteins limits the rapid transcriptional reprogramming induced by daunorubicin in acute myeloid leukemias
por: Boulanger, Mathias, et al.
Publicado: (2023)

DeSUMOylation of a Verticillium dahliae enolase facilitates virulence by derepressing the expression of the effector VdSCP8
por: Wu, Xue-Ming, et al.
Publicado: (2023)

Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV
por: Liu, Fengting, et al.
Publicado: (2018)

Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV
por: Liu, Fengting, et al.
Publicado: (2019)

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure
por: Huang, Chih-Yang, et al.
Publicado: (2017)

Correction to: SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair
Publicado: (2022)

The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation
por: Liebelt, Frauke, et al.
Publicado: (2019)

Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation
por: Bai, Yu-Ting, et al.
Publicado: (2021)

Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development
por: Yamada, Seiya, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e8sjm46l8fsvfdr07blmkf8e3f