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Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

Focal adhesions (FA) are large macromolecular assemblies which help transmit mechanical forces and regulatory signals between the extracellular matrix and an interacting cell. Two key proteins talin and vinculin connecting integrin to actomyosin networks in the cell. Both proteins bind to F-actin an...

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Detalles Bibliográficos
Autores principales: Kelley, Charlotte F, Litschel, Thomas, Schumacher, Stephanie, Dedden, Dirk, Schwille, Petra, Mizuno, Naoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384861/
https://www.ncbi.nlm.nih.gov/pubmed/32657269
http://dx.doi.org/10.7554/eLife.56110