Targeting Rad51 as a strategy for the treatment of melanoma cells resistant to MAPK pathway inhibition

Rad51 is an essential factor of the homologous recombination DNA repair pathway and therefore plays an important role in maintaining genomic stability. We show that RAD51 and other homologous recombination repair genes are overexpressed in metastatic melanoma cell lines and in melanoma patient sampl...

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Detalles Bibliográficos
Autores principales: Makino, Elena, Fröhlich, Lisa Marie, Sinnberg, Tobias, Kosnopfel, Corinna, Sauer, Birgit, Garbe, Claus, Schittek, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385107/
https://www.ncbi.nlm.nih.gov/pubmed/32719412
http://dx.doi.org/10.1038/s41419-020-2702-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385107/
https://www.ncbi.nlm.nih.gov/pubmed/32719412
http://dx.doi.org/10.1038/s41419-020-2702-y

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