Cargando…
Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer
Ciclopirox (CPX) modulates multiple cellular pathways involved in the growth of a variety of tumor cell types. However, the effects of CPX on colorectal cancer (CRC) and the underlying mechanisms for its antitumor activity remain unclear. Herein, we report that CPX exhibited strong antitumorigenic p...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385140/ https://www.ncbi.nlm.nih.gov/pubmed/32719342 http://dx.doi.org/10.1038/s41419-020-02779-1 |