Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

Ciclopirox (CPX) modulates multiple cellular pathways involved in the growth of a variety of tumor cell types. However, the effects of CPX on colorectal cancer (CRC) and the underlying mechanisms for its antitumor activity remain unclear. Herein, we report that CPX exhibited strong antitumorigenic p...

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Detalles Bibliográficos
Autores principales: Qi, Jianjun, Zhou, Ningning, Li, Liyi, Mo, Shouyong, Zhou, Yidan, Deng, Yao, Chen, Ting, Shan, Changliang, Chen, Qin, Lu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385140/
https://www.ncbi.nlm.nih.gov/pubmed/32719342
http://dx.doi.org/10.1038/s41419-020-02779-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385140/
https://www.ncbi.nlm.nih.gov/pubmed/32719342
http://dx.doi.org/10.1038/s41419-020-02779-1

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