Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN‐amplified neuroblastoma cells

MYCN gene amplification is consistently associated with poor prognosis in patients with neuroblastoma, a pediatric tumor arising from the sympathetic nervous system. Conventional anticancer drugs, such as alkylating agents and platinum compounds, have been used for the treatment of high‐risk patient...

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Detalles Bibliográficos
Autores principales: Yamashita, Ken, Kiyonari, Shinichi, Tsubota, Shoma, Kishida, Satoshi, Sakai, Ryuichi, Kadomatsu, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385364/
https://www.ncbi.nlm.nih.gov/pubmed/32415892
http://dx.doi.org/10.1111/cas.14485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385364/
https://www.ncbi.nlm.nih.gov/pubmed/32415892
http://dx.doi.org/10.1111/cas.14485

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