Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody‐dependent HER4 intracellular domain trafficking

Human epidermal growth factor receptor 4 (HER4) isoforms have oncogenic or tumor suppressor functions depending on their susceptibility to proteolytic cleavage and HER4 intracellular domain (4ICD) translocation. Here, we report that the neuregulin 1 (NRG1) tumor suppressor mechanism through the HER4...

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Detalles Bibliográficos
Autores principales: Lanotte, Romain, Garambois, Véronique, Gaborit, Nadège, Larbouret, Christel, Musnier, Astrid, Martineau, Pierre, Pèlegrin, André, Chardès, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385388/
https://www.ncbi.nlm.nih.gov/pubmed/32415868
http://dx.doi.org/10.1111/cas.14458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385388/
https://www.ncbi.nlm.nih.gov/pubmed/32415868
http://dx.doi.org/10.1111/cas.14458

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