Evaluation of Biased and Balanced Salvinorin A Analogs in Preclinical Models of Pain

In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential. Salvinorin A (SalA) is a potent and selective KOPr agonist, however, clinical utility is limited by the short duration of...

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Detalles Bibliográficos
Autores principales: Paton, Kelly F., Biggerstaff, Andrew, Kaska, Sophia, Crowley, Rachel S., La Flamme, Anne C., Prisinzano, Thomas E., Kivell, Bronwyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385413/
https://www.ncbi.nlm.nih.gov/pubmed/32792903
http://dx.doi.org/10.3389/fnins.2020.00765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385413/
https://www.ncbi.nlm.nih.gov/pubmed/32792903
http://dx.doi.org/10.3389/fnins.2020.00765

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