Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin

Effects of different genotypes on the pharmacokinetics of probe substrates may support their use as phenotyping agents for the activity of the respective enzyme or transporter. Digoxin is recommended as a probe substrate to assess the activity of the transporter P-glycoprotein (P-gp) in humans. Curr...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsin, Chih-hsuan, Stoffel, Marc S., Gazzaz, Malaz, Schaeffeler, Elke, Schwab, Matthias, Fuhr, Uwe, Taubert, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385621/
https://www.ncbi.nlm.nih.gov/pubmed/32719417
http://dx.doi.org/10.1038/s41598-020-69326-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385621/
https://www.ncbi.nlm.nih.gov/pubmed/32719417
http://dx.doi.org/10.1038/s41598-020-69326-y

Ejemplares similares