Mithramycin selectively attenuates DNA-damage-induced neuronal cell death

DNA damage triggers cell death mechanisms contributing to neuronal loss and cognitive decline in neurological disorders, including traumatic brain injury (TBI), and as a side effect of chemotherapy. Mithramycin, which competitively targets chromatin-binding sites of specificity protein 1 (Sp1), was...

Descripción completa

Detalles Bibliográficos
Autores principales: Makarevich, Oleg, Sabirzhanov, Boris, Aubrecht, Taryn G., Glaser, Ethan P., Polster, Brian M., Henry, Rebecca J., Faden, Alan I., Stoica, Bogdan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385624/
https://www.ncbi.nlm.nih.gov/pubmed/32719328
http://dx.doi.org/10.1038/s41419-020-02774-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385624/
https://www.ncbi.nlm.nih.gov/pubmed/32719328
http://dx.doi.org/10.1038/s41419-020-02774-6

Ejemplares similares