Bovine breed-specific augmented reference graphs facilitate accurate sequence read mapping and unbiased variant discovery

BACKGROUND: The current bovine genomic reference sequence was assembled from a Hereford cow. The resulting linear assembly lacks diversity because it does not contain allelic variation, a drawback of linear references that causes reference allele bias. High nucleotide diversity and the separation of...

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Detalles Bibliográficos
Autores principales: Crysnanto, Danang, Pausch, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385871/
https://www.ncbi.nlm.nih.gov/pubmed/32718320
http://dx.doi.org/10.1186/s13059-020-02105-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385871/
https://www.ncbi.nlm.nih.gov/pubmed/32718320
http://dx.doi.org/10.1186/s13059-020-02105-0

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