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Bovine breed-specific augmented reference graphs facilitate accurate sequence read mapping and unbiased variant discovery
BACKGROUND: The current bovine genomic reference sequence was assembled from a Hereford cow. The resulting linear assembly lacks diversity because it does not contain allelic variation, a drawback of linear references that causes reference allele bias. High nucleotide diversity and the separation of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385871/ https://www.ncbi.nlm.nih.gov/pubmed/32718320 http://dx.doi.org/10.1186/s13059-020-02105-0 |